Isolation and Structure Determination of Stigmaterol from the Stem Bark of Lansium domesticum Corr. Cv. Kokossan

Indonesia is a tropical country with biodiversity and source of natural compounds such as terpenoids, phenolic, flavonoids, alkaloid groups. The steroid one the large groups terpenoid various structures bioactivities. was also commonly found in Meliaceae family. One species this family Lansium domesticum Corr. which has been studied to have activities from isolated (limonoids, sesquiterpenoids, onoceranoids, cycloartanoids, steroids) well their extracts antidiarrheal, antimalarial, antimicrobial, antiinsecticide, antifeedant were used traditional medicine eye drops scorpion stings. n -hexane fraction bark L. Cor. cv. Kokosan produced whose structure determined by IR, 1 H-NMR, 13 C-NMR, DEPT spectroscopy methods compared literature. It concluded that (22 E )-stigmasta-5,22-dien-3ol first genus. This compound inactive against MCF-7 breast cancer cells an IC 50 value 832.14 µM.